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  • May 2025

RGA Brief: US drug overdose deaths drop to near pre-pandemic levels

Drug overdose mortality declined 27% in 2024 and is projected to reach the lowest level since 2019

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In Brief

Drug overdose deaths in the US dropped 27% in 2024, approaching pre-pandemic levels. Competing factors make it challenging to determine whether this trend will continue.

Key takeaways

  • US drug overdose deaths decreased 27% in 2024, projecting to reach the lowest level since 2019, potentially due to broader access to treatments and heightened awareness of the risks of drug use.
  • Alcohol-induced mortality has also declined since 2022, highlighting the broader topic of substance use in the US.
  • Trends in substance-related mortality vary significantly by demographics and between general and insured populations, posing challenges for insurers in assessing risk.

Drug overdose deaths for the US general population have been decreasing since 2023 – a notable change from the previous spikes that occurred during the acute phase of the COVID-19 pandemic. Increases in opioid-related overdose deaths were originally fueled by relaxed prescribing of prescription opioids;2 however, overdoses in the past decade have predominantly involved illegally manufactured fentanyl.3  

Various factors may be contributing to the recent declines, including broader access to treatments and increased awareness of the risks of using drugs like fentanyl. Regulations and access to treatment vary significantly by state, with known regional differences in drug overdose mortality trends.4  

While drug overdose mortality is currently decreasing, competing factors make it difficult to gauge if improving trends will continue or perhaps reverse. Potential challenges include contamination of drugs with more potent substances, which may not respond as effectively to overdose reversal medications.3 

The general population drug overdose mortality trends vary significantly by different demographics, such as geography, education level, and age. For example, individuals with lower education levels tend to experience higher drug overdose mortality rates as shown in Figure 2. 


Woman on a laptop, taking notes
Coming soon: A study from the Society of Actuaries Research Institute, authored by RGA, dives into trends, drivers, and considerations for insurers on overdose deaths.

What about alcohol?

Other substance usage also created concerns regarding mortality trends. Alcohol-induced mortality showed spikes in 2020 and 2021 but has declined since 2022.5 While the nature of these deaths vary – drug overdose deaths are acute, while alcohol-induced deaths tend to be more chronic – they both reflect overall substance use and related mortality trends within the US. According to the results of the National Survey on Drug Use and Health for 2023, approximately 47.5% of respondents aged 12 or older reported any alcohol use in the 30 days before the interview, as shown in Figure 3.  

 

Inside the insured population

Trends are expected to vary between general and insured populations. Within the insured population, substance-related deaths may vary by key policy details or demographics, such as policy year or age. Understanding these differences is critical for insurers to better assess the impact of these trends. Insurers must also consider the risks related to today’s underwriting methods and the interrelationship to other risk factors such as mental illness. There is potential for long-term risk related to substance use that may not yet be seen.  

Conclusion

In light of the dynamic environment surrounding drug overdose mortality and substance use disorder, the Society of Actuaries is taking a deep dive into the trends, drivers, and considerations for insurers. The report from the SOA and authored by RGA is expected to be published in the coming months. It will elaborate on these findings and will also include analyses of trends for both general and insured populations within the US.  


With thanks to Hilary Henly, Sara Goldberg, Dan Brandt, and Julianne Callaway for their contributions on this research.

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Meet the Authors & Experts

Kaitlyn-Fleigle
Author
Kaitlyn Fleigle
Actuary, Strategic Research, Global Actuarial Pricing and Research

References

  1. CDC, National Center for Health Statistics, "U.S. Overdose Deaths Decrease Almost 27% in 2024," 2025. 
  2. U.S. Congress, "The Opioid Crisis in the United States: A Brief History," 2022. 
  3. L. J. Tanz, A. Stewart, R. M. Gladden, J. Y. Ko, L. Owens and J. O'Donnell, "Detection of Illegally Manufactured Fentanyls and Carfentanil in Drug Overdose Deaths — United States, 2021–2024," MMWR Morb Mortal Wkly Rep 2024;73;1099-1105, 5 December 2024. 
  4. M. Widoff, "Saving Lives: State Strategies for Combating Overdose," National Conference of State Legislatures, 2025. 
  5. K. Fleigle and H. Henly, "A Post-Pandemic View of Alcohol Consumption: Insights on rising alcohol-induced mortality and liver disease," Reinsurance Group of America, Inc., 2025.