Underwriting and Claims
  • Research and White Papers
  • November 2025

A Turning Tide? How Insurers Can Navigate an Evolving Substance Use Crisis

By
  • Kaitlyn Fleigle
  • Hilary Henly
  • Sara Goldberg
  • Dan Brandt, FSA, FLMI
  • Julianne Callaway
Skip to Authors and Experts
Open pill bottle with pills on table
In Brief

A new SOA/RGA study shows that after years of rising drug overdose deaths, preliminary 2024 data indicate a potential turning point, with the first sustained decline in more than two decades. The analysis also found that alcohol presents mortality impacts relevant to the insurance industry, and discussions with internal experts highlighted various considerations for insurers. 

Read the full research paper here.

Key takeaways

  • Drug overdose deaths declined for the first time in decades, dropping roughly 3% in 2023 and showing a nearly 27% decrease in provisional 2024 data. This represents the first sustained decline after years of increases.
  • Alcohol poses a greater mortality risk than drug overdoses for university-educated populations, with alcohol-induced deaths surpassing drug overdose deaths in recent years, starting in 2019. This trend is particularly relevant for insurers given the demographic profile of their customer base.
  • RGA's insured data follows similar patterns as the general population, with drug- and alcohol-related claims peaking in 2021 and declining since, though 2023 rates remain elevated compared to pre-pandemic levels.

Drug overdose deaths skyrocketed from 17,000 in 1999 to nearly 108,000 in 2022, driven largely by the involvement of opioids. These deaths dropped to approximately 105,000 in 2023. At the time of the analysis, provisional data suggests an even more dramatic 27% decline in 2024, marking the first sustained decrease in a crisis that has claimed hundreds of thousands of lives.

For insurers, this shift represents both hope and complexity. While substance-related mortality has declined, there remains an ever-evolving set of drivers and considerations for insurers.

Man reading report on his computer
Go deeper. The full research paper offers more details and practical considerations on how to respond to the new data based on analyses of both the general and insured populations, medical literature review, and discussions with internal RGA experts.

The five waves behind a crisis

The drug overdose crisis unfolded in phases, each generally more deadly than the last.


The hidden alcohol crisis

While headlines tend to focus on opioids and drug overdose deaths, alcohol may present a more significant threat to the insured population.


The data reveals stark differences in how substances affect various populations. For example, alcohol-induced deaths typically occur at older ages, likely due to chronic conditions such as liver disease, while drug overdose deaths claim younger lives.  

Geographic and demographic disparities

The drug overdose crisis affects demographic groups differently. The highest mortality risks are faced by males, unmarried individuals, those with lower education levels, and workers in construction-related occupations. In fact, one alarming finding shows that around 25%-30% of all deaths for those aged 25-39 were attributed to drug overdoses in 2023.

Geographically, Eastern states have seen more improvement than Western states for 2024 drug overdose death rates, with some Eastern regions dropping 36% below pre-pandemic levels, while Oregon, Washington, and Alaska remain 130%-150% above 2019 levels.


These disparities can reflect complex socioeconomic factors, including income inequality, access to healthcare, and treatment availability. 

Treatment revolution

Recent advances in treatment accessibility may be driving the mortality decline. The removal of DEA X-waiver requirements for buprenorphine prescriptions in 2023 expanded access to medication-assisted treatment. Over-the-counter naloxone approvals have made overdose reversal medications widely available, and increased legality of drug checking equipment have further enhanced risk reduction measures.

Emerging treatments such as GLP-1 drugs, originally developed for diabetes and now used to treat obesity, show promise for addiction treatment. These medications are expressed in brain areas influenced by addictive substances and may represent a new frontier in substance use disorder treatment.

Insured population insights

RGA's analysis of over 6,900 alcohol- and drug-related claims from 2011 to 2023 reveals patterns that mirror but do not perfectly match general US population trends. Substance-related mortality in the insured population peaked in 2021, with rates increasing 13% annually between 2019 and 2021 followed by an annual 2% decline.


Reading between the lines

As the industry moves to better align underwriting processes with consumer demands, traditional fluid testing becomes less common. It is important for underwriters to be able to identify potential substance use disorders through less direct indicators.

Red flags include histories of trauma, mental illness, extended sick leave, or accidents. Medical signs such as hypertension, palpitations, gastrointestinal issues, or liver function abnormalities warrant closer scrutiny. Prescription patterns – particularly multiple prescribers, frequent renewals, or extended durations – can signal potential misuse.

The correlation between mental health and substance use disorders is important to understand. One-third of adults with mental illness had a substance use disorder in 2023, and those with mental illness were more likely to use illicit drugs, misuse opioids, and binge alcohol compared to those with no mental illness.

Global context and future outlook

The US leads the world in drug-related mortality, largely due to unique factors including prescription marketing practices, supply chain differences, and limited supervised consumption sites. Comparisons with Canada show similar trends but lower overall mortality rates.

The future remains uncertain. While recent declines offer hope, the contamination of drug supplies with novel substances poses ongoing risks. 


Woman at computer
Discover the latest additions and depth of resources on RGA's alcohol consumption resource hub.

Conclusion: Strategic implications for insurers

The evolving substance use crisis demands a nuanced approach to risk assessment. The focus on drug overdoses must expand to include alcohol’s significant impact, particularly on higher-educated populations which may be more representative of an insured population. 

These findings highlight the importance of considering the differences in cause-of-death trends between the general and insured populations when setting mortality improvement assumptions. While substance-related deaths have had a larger impact on general population mortality, the insured population shows similar experience patterns. Nevertheless, it is important for underwriters to be aware of the subtle indicators — medical, social, and behavioral — that could indicate a potential substance use disorder.

The encouraging decline in substance-related mortality offers hope, but insurers must remain vigilant. The crisis has evolved through multiple waves, each bringing new challenges. Success in navigating this landscape requires continuous monitoring, adaptive strategies, and recognition that the battle against substance-related mortality is far from over.


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Meet the Authors & Experts

Kaitlyn-Fleigle
Author
Kaitlyn Fleigle
Actuary, Strategic Research, Global Actuarial Pricing and Research
Hilary Henly
Author
Hilary Henly
Global Medical Researcher, Strategic Research 
Sara Goldberg
Author
Sara Goldberg
Vice President and Actuary, Pricing
Dan Brandt
Author
Dan Brandt, FSA, FLMI
Vice President & Actuary, Experience Studies & Analytics, US Individual Life
Julianne Callaway
Author
Julianne Callaway
Vice President and Senior Actuary, Strategic Research, Global Actuarial Pricing and Research

References

See full report for list of citations