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  • June 2025

Non-Traditional Risk Factors: Can musculoskeletal fitness enhance risk profile differentiation?

By
  • Dr. Lauren Acton
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In Brief
This article, from RGA's ReFlections newsletter, Dr. Lauren Acton examines the critical role of musculoskeletal fitness in health and longevity, emphasizing its potential applications in insurance risk assessment and claims management. The article also highlights the challenges and opportunities in measuring and incorporating muscle mass, strength, and functional capacity into insurance practices.

Key takeaways

  • Musculoskeletal fitness, particularly muscle strength and mass, is an important yet underutilized factor in health risk assessment. It plays a crucial role in mobility, metabolic health, and recovery from illness or injury, making it a valuable consideration for insurers in both underwriting and claims processes.
  • Incorporating muscle mass and strength measurements into risk assessments can enhance risk profile differentiation and provide more accurate health evaluations than traditional metrics.
  • Advancements in technology and functional assessments offer promising opportunities for insurers. As the industry moves toward digitization, a variety of tools may make it increasingly feasible to incorporate musculoskeletal fitness into risk assessment strategies.

 

Musculoskeletal fitness has also been extensively researched and is increasingly emphasized by clinicians as a marker of wellness and a target for health maintenance. Skeletal muscle is essential for functional abilities that support mobility, independence, and overall quality of life, particularly as we age. Strength and resistance training help preserve these abilities, reduce mortality and morbidity, and reinforce the connection between musculoskeletal health and longevity.

Given that skeletal muscle comprises approximately 40% of body mass in healthy individuals, understanding its role in health and risk assessment is increasingly relevant.1 This article explores musculoskeletal fitness, focusing on the importance of muscle strength and mass and potential impact in an insurance setting.

The ability to move

The musculoskeletal system is primarily responsible for physical function and mobility. Skeletal muscle enables us to perform a wide range of activities, ranging from essential daily tasks – such as bathing, dressing, eating, or getting from place to place – to more complex recreational and athletic pursuits that contribute to both health and personal fulfillment. In many occupations, a healthy musculoskeletal system is often crucial, where tasks are not only cognitive in nature but also require physical strength and endurance.

The ability to regulate and recover

  Woman lifting weights with trainer 

Beyond mobility, skeletal muscle serves as a critical source of protein (amino acids) and plays a key role in metabolic, cellular, and immune functions. It also helps regulate insulin and glucose metabolism.

The crucial role of muscle becomes even more apparent in the context of acute and chronic illnesses or traumatic injury, where the body’s demand for recovery and healing increases significantly. Higher muscle mass has been linked to improved survival rates in patients with chronic conditions, sepsis, cancer, ICU admission or those with severe burns.2,3

Regarding insulin and glucose metabolism, muscle tissue is the primary site for glucose and triglyceride utilization. Research indicates that greater muscle mass and strength and higher muscle-to-fat ratio are associated with lower insulin resistance, while low muscle strength has been linked to a higher prevalence of type 2 diabetes.2,4

The ability to protect

Age-related loss of skeletal muscle mass (known as sarcopenia) is associated with osteopenia (lower bone density). Muscle contractions and weight-bearing exercises apply mechanical force to bones, stimulating bone formation and maintaining bone density. This mechanical force, along with muscle contraction, plays a crucial role in maintaining bone health.3

After age 30, muscle mass declines by an estimated 3% to 8% per decade in individuals who do not participate in strength or resistance training, with an even greater decline after age 60.4 Bone mineral density also decreases by 1% to 3% annually.5 In addition to muscle loss, declining muscle strength – referred to as dynapenia – further increases the risk of frailty, falls, injury, and loss of mobility and independence as we age.

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Why musculoskeletal fitness is more relevant than ever

With cardiovascular disease, stroke, and cancer among the leading causes of death,6 addressing chronic disease management and prevention, physical inactivity, and sedentary behavior is essential – not only for improving patient outcomes but also for insurers assessing long-term risk.

Given the crucial role skeletal muscle plays in overall health, musculoskeletal health and fitness deserves greater attention. Exercise guidelines in both the UK and US recommend engaging in strength-based activities targeting all major muscle groups – legs, hips, back, abdomen, chest, shoulders, and arms – at least twice a week.7,8

Proper strength-training techniques and weight-bearing exercises help mitigate muscle loss, maintain strength, and preserve bone density, all of which are critical for sustaining physical mobility, function, and independence as we age.

Why insurers should consider musculoskeletal fitness in risk assessment

Insurers have a unique opportunity to promote health and wellness through education and preventive initiatives. Emphasizing the importance of musculoskeletal fitness and the benefits of strength and resistance training can encourage policyholders to adopt healthier habits, potentially leading to positive outcomes for both the policyholder and the insurer.

  Woman running while wearing headphones 
Muscle mass and strength provide valuable insights into body composition, functional abilities, and metabolic health, enhancing current risk assessment methods.

For example, within a given BMI range, the muscle-to-fat ratio can help refine risk segmentation. Highly muscular individuals may be misclassified under traditional BMI metrics, and as body composition shifts with age, assessing muscle mass relative to fat can offer a more precise evaluation of health risk. These considerations align with the ongoing reassessment of BMI as a measure of adiposity.9

In claims assessments, muscle strength and mass serve as non-traditional risk factors that may improve evaluations of prognosis, recovery timelines, and return-to-work potential for acutely or chronically ill individuals. Conversely, prolonged immobility due to acute traumatic injuries or chronic illnesses can contribute to musculoskeletal decline, further impacting health outcomes and claim duration.

Challenges with measuring muscle mass and strength

  Man lifting weights 

Assessing muscle mass and strength involves several techniques, each with varying accuracy, accessibility, and cost. While this poses challenges, it does not diminish the potential value of incorporating musculoskeletal health into underwriting or claims – provided the technique used is accurate, validated, affordable, and accessible.

Body composition, including fat, muscle, and bone mass, can be measured using dual-energy x-ray absorptiometry (DEXA), bioelectrical impedance analysis, CT, or MRI. DEXA scans are sometimes available for osteoporosis screening, whereas CT and MRI are not routinely used for this purpose. Additionally, smart scales connected to wearable devices can provide estimates of body composition.

Handheld dynamometers are another tool, offering a portable means of evaluating grip strength, which research has identified as a strong indicator of overall muscle strength. Studies have linked poor hand-grip strength to adverse clinical outcomes, while emerging evidence also suggests that lower-limb weakness correlates with increased mortality risk.2,4

Insurers should evaluate the feasibility, accuracy, accessibility, and affordability of these measurement techniques within specific risk segments such as the older populations, or with relevance to specific products – such as longevity and frail-care cover – based on regional and market considerations. While some markets may not yet have access to suitable methods, advancements in technology may expand these capabilities in the future.

ReFlections - June 2025
Explore ReFlections, the industry's premier medical underwriting publication, to learn more about key medical issues impacting the insurance industry.

The role of functional assessments

Assessments regarding muscle strength, mobility, gait, or endurance can provide insights that can help fine-tune risk for older lives or segment risks across preferred, standard, and substandard pools. Table 1 lists functional assessments that can be used at underwriting or claims stage depending on the risk presented.

Table 1: Common Methods for Assessing Functional Capacity and Musculoskeletal Function

Assessment of Exercise Functional Capacity or Endurance

Standard Bruce treadmill protocolWidely used for cardiac stress testing, involving progressive increase in speed and incline every three minutes.
Modified Bruce protocol, Balke, Naughton, and other individualized protocolsTreadmill protocols using lower rate of exercise provocation – used to accommodate older patients or those who are deconditioned.
Six-minute walk testA submaximal exercise test that can be used to assess functional capacity and endurance in cardiopulmonary or older patients.

Assessment of Gait

Assessment of gait speedTimed walk over short distances, such as 4 m.
Is a non-aerobic exercise that can gauge functional status.
Visual assessment of gait patternVisual assessment of gait speed or inspection for irregularities, such as shuffling gait, walking with imbalance, stooped posture, flat-footedness, foot drop, Trendelenburg or compensated Trendelenburg gait, kyphoscoliotic changes that may shift center of mass and pelvic obliquity.

Assessment of Muscle Strength

Assessment of grip strengthEvaluated using handheld dynamometer, squeezed tightly, with multiple readings obtained from both hands.
Reflects overall muscle strength.
Assessment of lower limb strengthCan evaluate by assessing quadricep strength in performing walking lunges, or a double leg squat.
Can evaluate number of sit-to-stand during 30 s to assess for leg strength and endurance.

Evaluation of Balance

Standing balance testsExamples include standing on one foot for 10 s minimum, standing with eyes closed, tandem standing, Romberg’s test, or performance of tandem walking.
Short physical performance batteryA battery of 3 tests that assess lower extremity function: evaluation of gait speed, performance of repeated chair rise, and standing balance.
Timed up and go testRise from armchair, walk 10 ft, turn around, and walk back to chair.
Integrates assessment of gait speed and balance.


Functional assessments provide valuable insights into mobility, strength, and overall physical function, particularly in aging populations or individuals recovering from illness or injury. Many of these assessments currently require in-person or online evaluation by a trained professional, making cost and efficiency key considerations for insurers. However, as the industry moves toward digitization, advancements in medical tools and wearables with embedded sensors may streamline data collection on gait, balance, and fall risk – potentially enhancing underwriting processes.

For claims assessments, functional capacity evaluations are already integrated into some markets and are typically conducted by occupational therapists. These evaluations frequently assess grip strength, muscle strength, and muscle wasting, all of which can provide essential insights.

For example, a claimant recovering from a prolonged ICU stay or chemotherapy may exhibit reduced grip strength and muscle wasting, requiring additional rehabilitation time. Incorporating these factors into claims assessments allows insurers to set more realistic return-to-work expectations and tailor interventions to support recovery.

Optimizing assessments for risk segmentation

While a range of functional assessments exist, insurers should weigh their time, cost, and effectiveness based on the level of risk exposure. For example:

  • For elderly applicants, gait and balance tests can help assess frailty, mobility loss, and fall risk, informing long-term care underwriting.
  • For rehabilitation claims, grip strength tests may serve as an efficient predictor of recovery trajectory.

Strategic selection of assessments, coupled with evolving technology, could help insurers enhance onboarding process and refine risk segmentation, leading to more personalized underwriting and claims strategies.

Expanding risk assessment through musculoskeletal insights

Musculoskeletal fitness, particularly muscle strength and mass, along with functional assessment tools, represents a valuable yet underutilized set of risk factors. These health indicators can enhance risk profile differentiation, better inform on return-to-work potential, and improve overall prognoses.

Insurers are encouraged to explore non-traditional risk factors where they align with accuracy, feasibility, and market relevance. As technology continues to evolve, ongoing evaluation of these advancements may reshape the way insurers approach, assess, and personalize risk management strategies.


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Meet the Authors & Experts

Lauren Acton
Author
Dr. Lauren Acton
Chief Medical Officer, RGA South Africa

References

  1. McLeod M, Breen L, Hamilton DL, Philp A. Live strong and prosper: the importance of skeletal muscle strength for healthy ageing. Biogerontology. 2016 Jun; 17(3): 497-510. doi: 10.1007/s10522-015-9631-7 Epub 2016 Jan 20. PMID: 26791164 PMCID: PMC4889643
  2. Al-Ozairi E, Alsaeed D, Alroudhan D, Voase N, Hasan A, Gill JMR, Sattar N, Welsh P, Gray CM, Boonpor J, Celis-Morales C, Gray SR. Skeletal Muscle and Metabolic Health: How Do We Increase Muscle Mass and Function in People with Type 2 Diabetes? J Clin Endocrinol Metab. 2021 Jan 23; 106(2): 309-317. doi: 10.1210/clinem/dgaa835 PMID: 33336682
  3. Wolfe RR. The underappreciated role of muscle in health and disease. Am J Clin Nutr. 2006 Sep; 84(3): 475-82. doi: 10.1093/ajcn/84.3.475 PMID: 16960159
  4. D’Onofrio G, Kirschner J, Prather H, Goldman D, Rozanski A. Musculoskeletal exercise: Its role in promoting health and longevity. Progress in Cardiovascular Diseases, Volume 77, 2023, Pages 25-36, ISSN 0033-0620, https://doi.org/10.1016/j.pcad.2023.02.006
  5. Westcott WL. Resistance training is medicine: effects of strength training on health. Curr Sports Med Rep. 2012 Jul-Aug; 11(4):209-16. doi: 10.1249/JSR.0b013e31825dabb8 PMID: 22777332
  6. https://www.who.int/news-room/fact-sheets/detail/the-top-10-causes-of-death accessed 13/2/2025
  7. US Department of Health and Human Services. Physical Activity Guidelines for Americans, 2nd edition. Washington, DC: US Department of Health and Human Services; 2018
  8. UK Chief Medical Officers’ Physical Activity Guidelines, 2019
  9. Rubino, Francesco et al. Definition and diagnostic criteria of clinical obesity. The Lancet Diabetes & Endocrinology, Volume 13, Issue 3, 221-262